A number of methods have emerged in an attempt to boost cellular rejuvenation and decrease the effects of aging. The most common one is based on nutrition; supported by dietary energy regulation. Based on a body of work published in Oncotarget, the significance of dieting and nutrition on extending lifespan and the deceleration of aging has grown immensely. Dietary energy regulation can be in the form of either calorie restriction or dietary restriction. In most cases, the two terms are used synonymously, but they bear ample differences.
Dietary restriction (DR) is achieved by simply decreasing the amount of food allocated per serving, while calorie restriction (CR) is accomplished by reducing the energy concentration by changing the composition of your diet. This means that CR requires more effort than DR, and this is why the use of DR is emphasized more for lifespan-lengthening activities. Using DR regimens are responsible for the deactivation of anabolic pathways for nutrients during fasting. Therefore, lifespan extension and cell rejuvenation processes are enhanced by the inhibition of mTOR functioning. Check the journal at SCImago Journal & Country Rank.
This is because mTOR activity invalidates rejuvenation because it limits the attainment of lifespan-lengthening effects brought about by DR. It also leads to aging and cellular degradation because of the repetitive distribution of nutrients caused by mTOR hyperactivity. Based on this, overeating or ad libitum feeding will lead to rapid aging. An energy-dense diet brings about accelerated aging, especially to those highly susceptible to diet-induced obesity. Because ad libitum feeding promotes obesity, a decrease in such patterns would lead to the unearthing of its hidden potential.
However, it has been discovered that cell rejuvenation based on DR methods will come at the expense of sexual reproduction and growth. The reason for this is that levels of major urinary proteins (MUPs) in the body decrease with the use of DR. This means that low MUPs levels lead to inhibited sexual growth.
It is a traditional free access journal that offers papers in Oncology, as well as other fields including, but not limited to Cell Biology, Anti-aging, Cardiology, and Neuroscience. The objective of Oncotarget is to avail scientific research findings promptly and ensure that authors increase the impression made by their research.
The current editors of Oncotarget are Mikhail Blagosklonny and Andrei V. Gudkov. The rights of works published online are retained by the authors, but through a Creative Commons Attribution License, other people can reuse, modify, distribute, and reprint articles. Visit Oncotarget’s profile page at facebook.com
Oncotarget is one of the leading online medical journals, with a 5-year impact factor of 5.415 by Scopus/SJR.